Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix.

@article{Parnaud2006BlockadeOB,
  title={Blockade of beta1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix.},
  author={G{\'e}raldine Parnaud and Eva Hammar and Dominique G. Rouiller and Mathieu Armanet and Philippe A. Halban and Domenico Bosco},
  journal={Diabetes},
  year={2006},
  volume={55 5},
  pages={1413-20}
}
When attached on a matrix produced by a rat bladder carcinoma cell line (804G matrix), rat pancreatic beta-cells spread in response to glucose and secrete more insulin compared with cells attached on poly-l-lysine. The aim of this study was to determine whether laminin-5 and its corresponding cell receptor beta1 integrin are implicated in these phenomena. By using specific blocking antibodies, we demonstrated that laminin-5 is the component present in 804G matrix responsible for the effect of… CONTINUE READING

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