Blockade of beta-adrenergic signaling does not influence the bone mechano-adaptive response in mice.

@article{Marenzana2007BlockadeOB,
  title={Blockade of beta-adrenergic signaling does not influence the bone mechano-adaptive response in mice.},
  author={Massimo Marenzana and Roberto Lopes de Souza and Chantal Chenu},
  journal={Bone},
  year={2007},
  volume={41 2},
  pages={206-15}
}
The involvement of the sympathetic nervous system (SNS) in the modulation of bone adaptation to its load-bearing demand remains controversial. This study tested the involvement of SNS in the adaptive response of trabecular and cortical bone to either external loading or disuse. External loading consisted of cyclic strain (40 cycles, peak 1500 microstrain) applied for 7 min, 3 days/week, while disuse was induced by unilateral sciatic neurectomy (SN). C57Bl/J6 mice, female, 9 weeks old, were… CONTINUE READING