Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression.

@article{Ohnuma2009BlockadeOA,
  title={Blockade of an angiotensin type I receptor enhances effects of radiation on tumor growth and tumor-associated angiogenesis by reducing vascular endothelial growth factor expression.},
  author={Yuichiro Ohnuma and Masaya Toda and Mamoru Fujita and Kanako Hosono and Tatsunori Suzuki and Yasuhumi Ogawa and Hideki Amano and Hidero Kitasato and Kazushige Hayakawa and Masataka C Majima},
  journal={Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie},
  year={2009},
  volume={63 2},
  pages={136-45}
}
OBJECTIVE Angiogenesis, the formation of new capillary blood vessels, is essential for tumor progression. We had reported that Type 1 angiotensin receptor (AT1-R) antagonist reduced tumor-associated angiogenesis. Since antiangiogenic agents were reported to enhance efficacy of radiation therapy, we tested here whether or not AT1-R blockade facilitates the effects of radiation. METHODS 1 x 10(6) LLC cells were injected into the subcutaneous tissue of male C57BL/6 mice, and when the average… CONTINUE READING

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