Blockade of airway sensory nerves and dyspnea in humans.

  title={Blockade of airway sensory nerves and dyspnea in humans.},
  author={Nausherwan K. Burki and L V Lee},
  journal={Pulmonary pharmacology & therapeutics},
  volume={23 4},
Evidence has accumulated from previous studies that vagal fibers in the lungs are involved in the genesis of dyspnea. In a series of human studies, based on our previous animal data (J Physiol 1998; 508:109-18; J Appl Physiol 1998; 84:417-24; J Appl Physiol 2003; 95:1315-24) we established that intravenous adenosine has a dyspnogenic effect (J Appl Physiol 2005; 98:180-5; Respir Res 2006; 7:139; Pulm Pharmacol Ther 2008; 21:208-13), strongly implicating a role for vagal C-fibers in the genesis… CONTINUE READING

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