Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice

@article{Boeck2009BlockadeOA,
  title={Blockade of adenosine A2A receptor counteracts neuropeptide-S-induced hyperlocomotion in mice},
  author={Carina Rodrigues Boeck and Caroline Martinello and Adalberto Alves de Castro and Morgana Moretti and Tiago dos Santos Casagrande and Remo Guerrini and Girolamo Calo’ and Elaine Cristina Gavioli},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2009},
  volume={381},
  pages={153-160}
}
Neuropeptide S (NPS) is the endogenous ligand of a G-protein-coupled receptor named as NPSR. Behavioral effects have been recently attributed to NPS, i.e. hyperlocomotion, anxiolysis, and wakefulness. However, little is known about the mechanisms by which NPS evokes such biological actions. The present study aimed to investigate the role played by the… CONTINUE READING