Blockade of a putative GABA-mediated neurotransmission in the cerebellum by benzodiazepine receptor inverse agonists.

@article{Gardner1986BlockadeOA,
  title={Blockade of a putative GABA-mediated neurotransmission in the cerebellum by benzodiazepine receptor inverse agonists.},
  author={C. Gardner},
  journal={Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology},
  year={1986},
  volume={85 1},
  pages={
          225-32
        }
}
  • C. Gardner
  • Published 1986
  • Biology, Medicine
  • Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology
An exponential relationship was observed between the firing rate of cerebellar Purkinje cells in urethane-anaesthetized rats and the duration of inhibition evoked in these cells by electrical stimulation of the nearby cortical surface. Benzodiazepines, administered i.v., decreased cell firing and increased the duration of the inhibitory response but did not alter the relationship between the two parameters. These effects of one benzodiazepine, RU 32007, were reversed by the benzodiazepine… Expand
3 Citations
Functional in vivo correlates of the benzodiazepine agonist-inverse agonist continuum
  • C. Gardner
  • Biology, Medicine
  • Progress in Neurobiology
  • 1988
GABA receptor mechanisms in the central nervous system

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