Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation.

@article{Sen2001BlockadeOW,
  title={Blockade of Wnt-5A/frizzled 5 signaling inhibits rheumatoid synoviocyte activation.},
  author={Malini Sen and Margarita Chamorro and Jack R Reifert and Maripat Corr and Dennis Anthony Carson},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 4},
  pages={772-81}
}
OBJECTIVE It is not understood why cultured fibroblast-like synoviocytes (FLS) from patients with rheumatoid arthritis (RA) often display a persistently activated phenotype, despite removal from an inflammatory environment. Previously, we found that these FLS expressed high levels of both Wnt-5A and Frizzled 5 (Fz5), a receptor-ligand pair implicated in both limb bud and bone marrow stem cell development. The objective of the present experiments was to determine whether Wnt-5A/FzS signaling… CONTINUE READING

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