Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the Eye

@inproceedings{Huang2011BlockadeOV,
  title={Blockade of VEGFR1 and 2 Suppresses Pathological Angiogenesis and Vascular Leakage in the Eye},
  author={Hu Huang and Jikui Shen and Stanley A. Vinores},
  booktitle={PloS one},
  year={2011}
}
OBJECTIVE VEGFR1 and 2 signaling have both been increasingly shown to mediate complications of ischemic retinopathies, including retinopathy of prematurity (ROP), age-related macular degeneration (AMD), and diabetic retinopathy (DR). This study evaluates the effects of blocking VEGFR1 and 2 on pathological angiogenesis and vascular leakage in ischemic retinopathy in a model of ROP and in choroidal neovascularization (CNV) in a model of AMD. MATERIALS AND METHODS Neutralizing antibodies… CONTINUE READING
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