Blockade of Tachykinin NK1/NK2 Receptors in the Brain Attenuates the Activation of Corticotrophin‐Releasing Hormone Neurones in the Hypothalamic Paraventricular Nucleus and the Sympathoadrenal and Pituitary‐Adrenal Responses to Formalin‐Induced Pain in the Rat

@article{Culman2010BlockadeOT,
  title={Blockade of Tachykinin NK1/NK2 Receptors in the Brain Attenuates the Activation of Corticotrophin‐Releasing Hormone Neurones in the Hypothalamic Paraventricular Nucleus and the Sympathoadrenal and Pituitary‐Adrenal Responses to Formalin‐Induced Pain in the Rat},
  author={J. Culman and G. Das and C. Ohlendorf and M. Haass and C. Maser-Gluth and M. Zuhayra and Y. Zhao and K. Itoi},
  journal={Journal of Neuroendocrinology},
  year={2010},
  volume={22}
}
  • J. Culman, G. Das, +5 authors K. Itoi
  • Published 2010
  • Chemistry, Medicine
  • Journal of Neuroendocrinology
  • Evidence from pharmacological studies has implicated substance P (SP), a natural ligand of tachykinin NK1 receptors which can also interact with NK2 receptors, in the generation of pressor and tachycardic responses to stress. Using selective blockade of brain NK1 and NK2 receptors, we tested in conscious rats the hypothesis that SP initiates, within the neuronal brain circuits, the sympathoadrenal, hypothalamic‐pituitary‐adrenal (HPA) and behavioural responses to noxious stimuli. Formalin… CONTINUE READING
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