Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis.

@article{Kanamaru2001BlockadeOT,
  title={Blockade of TGF-beta signaling in T cells prevents the development of experimental glomerulonephritis.},
  author={Yutaka Kanamaru and Atsunori Nakao and Mizuko Mamura and Yasuaki Suzuki and Isao Shirato and Ko Okumura and Yasuhiko Tomino and Chisei Ra},
  journal={Journal of immunology},
  year={2001},
  volume={166 4},
  pages={2818-23}
}
Anti-glomerular basement membrane (GBM) Ab-induced glomerulonephritis (GN) at late stage is thought to be mediated by T cells. However, signaling pathways of T cells that are involved in the development of anti-GBM Ab-induced GN are unclear. We have recently established transgenic mice expressing Smad7, an inhibitor of TGF-beta signaling, in mature T cells, where signaling by TGF-beta was blocked specifically in T cells. In this study, we showed that anti-GBM Ab-induced GN was suppressed in… CONTINUE READING

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