Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis

@article{Sakamoto2000BlockadeOT,
  title={Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis},
  author={Taiji Sakamoto and Hikaru Ueno and Koh-hei Sonoda and Toshio Hisatomi and Kiyoshi Shimizu and Hiromi Ohashi and Hajime Inomata},
  journal={Gene Therapy},
  year={2000},
  volume={7},
  pages={1915-1924}
}
Accumulating evidence suggests the involvement of TGF-β in the process of corneal opacity, which is one of the serious causes of visual loss. However, whether TGF-β is indeed critical for the pathogenesis remains unknown. We constructed an adenovirus expressing an entire ectodomain of the human type II TGF-β receptor fused to Fc portion of human IgG (AdTβ-ExR): this soluble receptor is secreted from AdTβ-ExR-infected cells, binds to TGF-β and inhibits TGF-β signaling. When AdTβ-ExR was injected… CONTINUE READING

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