Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection.

@article{Grgic2009BlockadeOT,
  title={Blockade of T-lymphocyte KCa3.1 and Kv1.3 channels as novel immunosuppression strategy to prevent kidney allograft rejection.},
  author={Ivica Grgic and Heike Wulff and Ines Eichler and Christoph Flothmann and Ralf K{\"o}hler and Joachim Hoyer},
  journal={Transplantation proceedings},
  year={2009},
  volume={41 6},
  pages={2601-6}
}
Currently, there is an unmet clinical need for novel immunosuppressive agents for long-term prevention of kidney transplant rejection as alternatives to the nephrotoxic calcineurin inhibitor cyclosporine (CsA). Recent studies have shown that K(+) channels have a crucial role in T-lymphocyte activity. We investigated whether combined blockade of the T-cell K(+) channels K(Ca)3.1 and K(v)1.3, both of which regulate calcium signaling during lymphocyte activation, is effective in prevention of… CONTINUE READING

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