Blockade of Rho/Rho-associated coiled coil-forming kinase signaling can prevent progression of hepatocellular carcinoma in matrix metalloproteinase-dependent manner.

@article{Xue2008BlockadeOR,
  title={Blockade of Rho/Rho-associated coiled coil-forming kinase signaling can prevent progression of hepatocellular carcinoma in matrix metalloproteinase-dependent manner.},
  author={Feng Xue and Terumi Takahara and Yutaka Yata and Qiang Xia and Kazunobu Nonome and Eiji Shinno and Masami Kanayama and Shiro Takahara and Toshiro Sugiyama},
  journal={Hepatology research : the official journal of the Japan Society of Hepatology},
  year={2008},
  volume={38 8},
  pages={810-7}
}
AIM There is growing evidence that the Rho/Rho-associated coiled coil-forming kinase (ROCK) signaling pathway is upregulated in tumors and plays a key role in cancer invasion and metastasis. Our aim was to test the anticancer effects of Rho/ROCK inhibitor, Y-27632, including possible mechanisms in a highly-metastasizing hepatocellular carcinoma (HCC) mouse model on its secretion of matrix metalloproteinase (MMP) and tumor progression. METHODS Following orthotopic implantation of CBO140C12 HCC… CONTINUE READING

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