Blockade of NMDA-receptors prevents ocularity changes in kitten visual cortex after reversed monocular deprivation.

@article{Gu1989BlockadeON,
  title={Blockade of NMDA-receptors prevents ocularity changes in kitten visual cortex after reversed monocular deprivation.},
  author={Q A Gu and Mark F. Bear and Wolf Singer},
  journal={Brain research. Developmental brain research},
  year={1989},
  volume={47 2},
  pages={281-8}
}
We investigated in the striate cortex of kittens whether the recovery from the effects of monocular deprivation that occurs after reverse occlusion requires activation of N-methyl-D-aspartate (NMDA) receptors. The right eye of 3-4-week-old kittens was closed by lid suture for one week. Subsequently this eye was reopened and the left eyelid sutured closed for another week. During this second week, the NMDA-receptor antagonist, 2-amino-5-phosphonovaleric acid (APV), was infused from an osmotic… CONTINUE READING