Blockade of NMDA channels in acutely isolated rat hippocampal neurons by the Na+/Ca2+ exchange inhibitor KB-R7943.

Abstract

Neurons acutely isolated from the CA1 region of rat hippocampal slices using the 'vibrodissociation' method were voltage-clamped in the whole-cell configuration. The currents through NMDA channels were elicited by application of 100 microM aspartate (ASP) in a Mg2+-free solution in the presence of 3 microM glycine. The compound KB-R7943, (2-[2-[4-(4… (More)

Topics

  • Presentations referencing similar topics