Blockade of Myocardial ATP-sensitive Potassium Channels by Ketamine

  title={Blockade of Myocardial ATP-sensitive Potassium Channels by Ketamine},
  author={Seong Hoon Ko and Su Kyung Lee and You Jin Han and Hyeon Gyu Choe and Yong Geun Kwak and Soo Wan Chae and Kyuhyang Cho and Huesup Song},
  volume={87 1},
BACKGROUND The adenosine triphosphate (ATP)-sensitive potassium (KATP) channel underlies the increase in potassium permeability during hypoxia and ischemia. The increased outward potassium current during ischemia may be an endogenous cardioprotective mechanism. This study was designed to determine the effects of ketamine on KATP channel in rat hearts. METHODS Inside-out and cell-attached configurations of patch-clamp techniques and 3 M potassium chloride-filled conventional microelectrodes… CONTINUE READING
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