Blockade of Intranigral and Systemic D3 Receptors Stimulates Motor Activity in the Rat Promoting a Reciprocal Interaction among Glutamate, Dopamine, and GABA

@article{RodrguezSnchez2019BlockadeOI,
  title={Blockade of Intranigral and Systemic D3 Receptors Stimulates Motor Activity in the Rat Promoting a Reciprocal Interaction among Glutamate, Dopamine, and GABA},
  author={Marina Rodr{\'i}guez-S{\'a}nchez and Rodrigo Erick Escart{\'i}n-P{\'e}rez and Gerardo Leyva-G{\'o}mez and Jos{\'e} Arturo {\'A}valos-Fuentes and Francisco Javier Paz-Berm{\'u}dez and Santiago Loya-L{\'o}pez and Jorge Aceves and David Erlij and Hern{\'a}n Cort{\'e}s and Benjam{\'i}n Flor{\'a}n},
  journal={Biomolecules},
  year={2019},
  volume={9}
}
In vivo activation of dopamine D3 receptors (D3Rs) depresses motor activity. D3Rs are widely expressed in subthalamic, striatal, and dendritic dopaminergic inputs into the substantia nigra pars reticulata (SNr). In vitro studies showed that nigral D3Rs modulate their neurotransmitter release; thus, it could be that these changes in neurotransmitter levels modify the discharge of nigro-thalamic neurons and, therefore, motor behavior. To determine how the in vitro responses correspond to the in… 

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