Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection

@inproceedings{Peppa2010BlockadeOI,
  title={Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection},
  author={Dimitra Peppa and Lorenzo Micco and Alia Javaid and Patrick T. F. Kennedy and Anna K C Schurich and Claire Dunn and Celeste Pallant and Gidon Ellis and Pooja Khanna and Geoffrey Dusheiko and Richard John Cary Gilson and Mala K Maini},
  booktitle={PLoS pathogens},
  year={2010}
}
NK cells are enriched in the liver, constituting around a third of intrahepatic lymphocytes. We have previously demonstrated that they upregulate the death ligand TRAIL in patients with chronic hepatitis B virus infection (CHB), allowing them to kill hepatocytes bearing TRAIL receptors. In this study we investigated whether, in addition to their pathogenic role, NK cells have antiviral potential in CHB. We characterised NK cell subsets and effector function in 64 patients with CHB compared to… CONTINUE READING
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Schurich A (2010) The molecular basis of the failed immune response in chronic HBV: therapeutic implications

  • MK Maini
  • J Hepatol
  • 2010
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