Blockade of IL-18 receptor signaling delays the onset of autoimmune disease in MRL-Faslpr mice.

@article{Kinoshita2004BlockadeOI,
  title={Blockade of IL-18 receptor signaling delays the onset of autoimmune disease in MRL-Faslpr mice.},
  author={Koji Kinoshita and Toshiaki Yamagata and Yuji Nozaki and Masafumi Sugiyama and Shinya Ikoma and Masunori Funauchi and Akihisa Kanamaru},
  journal={Journal of immunology},
  year={2004},
  volume={173 8},
  pages={5312-8}
}
Autoimmune disease in Fas-deficient MRL-Faslpr mice is dependent on infiltrating autoreactive leukocytes and autoantibodies, and IFN-gamma plays an important role in the pathogenesis. As IL-18 is capable of inducing IFN-gamma production in T cells, we hypothesized that signaling through IL-18R is involved in the pathogenesis. To investigate the impact of IL-18 in this autoimmune disease, we generated an MRL-Faslpr strain deficient in IL-18Ralpha. Compared with the wild-type strain, IL-18Ralpha… CONTINUE READING
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