Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.

@article{Qian2009BlockadeOH,
  title={Blockade of Hsp20 phosphorylation exacerbates cardiac ischemia/reperfusion injury by suppressed autophagy and increased cell death.},
  author={Jiang Qian and Xiaoping Ren and Xiaohong Wang and Pengyuan Zhang and Walter K. Jones and Jeffery D Molkentin and Guo-Chang Fan and Evangelia G Kranias},
  journal={Circulation research},
  year={2009},
  volume={105 12},
  pages={1223-31}
}
RATIONALE The levels of a small heat shock protein (Hsp)20 and its phosphorylation are increased on ischemic insults, and overexpression of Hsp20 protects the heart against ischemia/reperfusion injury. However, the mechanism underlying cardioprotection of Hsp20 and especially the role of its phosphorylation in regulating ischemia/reperfusion-induced autophagy, apoptosis, and necrosis remain to be clarified. OBJECTIVE Herein, we generated a cardiac-specific overexpression model, carrying… CONTINUE READING
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