• DOI:10.1016/0014-5793(96)00355-9
Corpus ID: 40355762

Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

@article{Suessbrich1996BlockadeOH,
  title={Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole},
  author={H. Suessbrich and S. Waldegger and F. Lang and A. Busch},
  journal={FEBS Letters},
  year={1996},
  volume={385}
}

H. Suessbrich, S. Waldegger, +1 author A. Busch

Published 1996

Chemistry, Medicine

FEBS Letters

The widely used histamine receptor antagonists terfenadine and astemizole were shown to prolong the QT interval in electrocardiographic recordings in cases of overdose or inappropriate co‐medications, indicating a possible interaction with cardiac K+ channels. Here, terfenadine and astemizole both inhibited the human ether‐a‐go‐go related gene (HERG) encoded channels expressed in Xenopus oocytes at nanomolar concentrations in a use‐ and voltage‐dependent fashion. In contrast, inhibition of… CONTINUE READING

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