Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole

@article{Suessbrich1996BlockadeOH,
  title={Blockade of HERG channels expressed in Xenopus oocytes by the histamine receptor antagonists terfenadine and astemizole},
  author={H. Suessbrich and S. Waldegger and F. Lang and A. Busch},
  journal={FEBS Letters},
  year={1996},
  volume={385}
}
  • H. Suessbrich, S. Waldegger, +1 author A. Busch
  • Published 1996
  • Chemistry, Medicine
  • FEBS Letters
  • The widely used histamine receptor antagonists terfenadine and astemizole were shown to prolong the QT interval in electrocardiographic recordings in cases of overdose or inappropriate co‐medications, indicating a possible interaction with cardiac K+ channels. Here, terfenadine and astemizole both inhibited the human ether‐a‐go‐go related gene (HERG) encoded channels expressed in Xenopus oocytes at nanomolar concentrations in a use‐ and voltage‐dependent fashion. In contrast, inhibition of… CONTINUE READING
    220 Citations

    Topics from this paper

    Inhibition of HERG1 K+ channels by the novel second‐generation antihistamine mizolastine
    • 36
    Block of HERG k channel by classic histamine h(1) receptor antagonist chlorpheniramine.
    • Hee-kyung Hong, Suhyun Jo
    • Chemistry, Medicine
    • The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
    • 2009
    • 9
    • PDF
    Inactivation gating determines drug potency: a common mechanism for drug blockade of HERG channels.
    • 28
    Blockade of HERG channels by the class III antiarrhythmic azimilide: mode of action
    • 55
    Inhibition of HERG potassium channels by the antimalarial agent halofantrine
    • 53
    Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel.
    • 39
    Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents.
    • 35
    • PDF
    The inhibitory effect of the antipsychotic drug haloperidol on HERG potassium channels expressed in Xenopus oocytes
    • 201
    Inhibition of cloned HERG potassium channels by the antiestrogen tamoxifen
    • 43

    References

    SHOWING 1-10 OF 17 REFERENCES