Blockade of HERG and Kv1.5 by ketoconazole.

@article{Dumaine1998BlockadeOH,
  title={Blockade of HERG and Kv1.5 by ketoconazole.},
  author={Robert Dumaine and Mathieu L. Roy and Arthur M. Brown},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={286 2},
  pages={727-35}
}
Ketoconazole, a widely used fungicide in patients, has been associated with Q-T prolongation and torsade de pointes when co-administered with terfenadine (Seldane). Both compounds use the same cytochrome-P450 metabolic pathway, resulting in an increase in plasma concentration of terfenadine. We previously showed that terfenadine blocked HERG (Human Ether-a-Gogo Related Gene), an important component of the repolarizing cardiac delayed rectifier IK with concentration needed to obtain 50% of the… CONTINUE READING

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