Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm

@article{MarichalCancino2016BlockadeOG,
  title={Blockade of GPR55 in the dorsolateral striatum impairs performance of rats in a T-maze paradigm},
  author={Bruno A. Marichal-Cancino and Asai S{\'a}nchez-Fuentes and M{\'o}nica M{\'e}ndez-Diaz and Alejandra E Ruiz-Contreras and Oscar E Prospero-Garcia},
  journal={Behavioural Pharmacology},
  year={2016},
  volume={27},
  pages={393–396}
}
To investigate the role of GPR55 receptors, which are expressed in human and rat striatum (a structure that regulates procedural memory), Wistar rats received five training sessions (10 trials/session, 1 session/day) to solve a T-maze paradigm. From these data, we constructed learning curves following pharmacological manipulation of GPR55. Five minutes before each session, animals received bilateral intradorsolateral striatum injections of noladin-ether (3.1 nmol/l; endogenous agonist of GPR55… 
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