Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia.

@article{Liu2002BlockadeOF,
  title={Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia.},
  author={Jin Hong Liu and Sheng Cheng Wei and Thierry Lamy and Yongxiang Li and Pearlie K Epling-Burnette and Julie Y. Djeu and Thomas P. Loughran},
  journal={Blood},
  year={2002},
  volume={100 4},
  pages={
          1449-53
        }
}
Altered expression of the Fas-Fas ligand apoptotic pathway leads to lymphoproliferative and autoimmune diseases. In lpr/lpr mice and children with autoimmune lymphoproliferative syndrome, defective apoptosis is due to Fas mutations. Large granular lymphocyte (LGL) leukemia is a clonal lymphoproliferative disorder associated with rheumatoid arthritis. Leukemic LGLs are resistant to Fas-dependent apoptosis despite expressing high levels of Fas. Such resistance can be overcome by activating… CONTINUE READING

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