Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27(KIP1) and MMP3 expression.

@article{Jin2013BlockadeOE,
  title={Blockade of EGFR signaling promotes glioma stem-like cell invasiveness by abolishing ID3-mediated inhibition of p27(KIP1) and MMP3 expression.},
  author={Xun Jin and Xiong Jie Jin and Young-Woo Sohn and Jinlong Yin and Sung Hak Kim and Kaushal Joshi and Do-Hyun Nam and Ichiro Nakano and Hyunggee Kim},
  journal={Cancer letters},
  year={2013},
  volume={328 2},
  pages={235-42}
}
Aberrant epidermal growth factor receptor (EGFR) signaling is a typical oncogenic signature in glioblastoma. Here, we show that EGFR inhibition in primary glioma stem cells (GSCs) with oncogenic EGFRvIII and EGFRvIII-transduced glioma stem-like cells promotes invasion by decreasing ID3 levels. ID3 suppresses GSC invasiveness by inhibiting p27(KIP1)-RhoA-dependent migration and MMP3 expression. Xenograft and human glioblastoma specimens show that ID3 localizes within glioblastoma cores, whereas… CONTINUE READING

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