Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.

@article{Zhou2006BlockadeOE,
  title={Blockade of EGFR and ErbB2 by the novel dual EGFR and ErbB2 tyrosine kinase inhibitor GW572016 sensitizes human colon carcinoma GEO cells to apoptosis.},
  author={Yunfei Zhou and Song Li and Yi Peter Hu and Jing Wang and Jennie Hauser and Alexis N Conway and Michelle A Vinci and Lisa Humphrey and Elizabeth Zborowska and James K. V. Willson and Michael G. Brattain},
  journal={Cancer research},
  year={2006},
  volume={66 1},
  pages={404-11}
}
Coexpression of the epidermal growth factor receptor (EGFR) family receptors is found in a subset of colon cancers, which may cooperatively promote cancer cell growth and survival, as heterodimerization is known to provide for diversification of signal transduction. Recently, efforts have been made to develop novel 4-anilinoquinazoline and pyridopyrimidine derivatives to inhibit EGFR and ErbB2 kinases simultaneously. In this study, we tested the efficacy of a novel reversible dual inhibitor… CONTINUE READING
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