Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice

  title={Blockade of CXCR1/2 chemokine receptors protects against brain damage in ischemic stroke in mice},
  author={Larissa Fonseca da Cunha Sousa and Fernanda Matos Coelho and David Rodrigues and Alline Cristina de Campos and Luc{\'i}ola da Silva Barcelos and Mauro M Teixeira and Milene Alvarenga Rachid and Ant{\^o}nio L{\'u}cio Teixeira},
OBJECTIVE Ischemic stroke may result from transient or permanent reductions of regional cerebral blood flow. Polymorphonuclear neutrophils have been described as the earliest inflammatory cells to arrive in ischemic tissue. CXCR1/2 receptors are involved in the recruitment of these cells. However, the contribution of these chemokine receptors during transient brain ischemia in mice remains poorly understood. In this work, we investigated the effects of reparixin, an allosteric antagonist of… CONTINUE READING
Highly Cited
This paper has 51 citations. REVIEW CITATIONS


Publications citing this paper.
Showing 1-10 of 17 extracted citations

51 Citations

Citations per Year
Semantic Scholar estimates that this publication has 51 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 23 references

Stroke. Lancet

  • GA Donnan, M Fisher, M Macleod, SM. Davis
  • 2008
1 Excerpt

Neuroprotection with the CXCL8 inhibitor reparixin in transient brain ischemia

  • A Garau, R Bertini, F Colotta, F Casilli, P Bigini, A Cagnotto
  • Cytokine. 2005;30(3):125-31,
  • 2004
2 Excerpts

Similar Papers

Loading similar papers…