Blockade of CTLA-4 (CD152) enhances the murine antibody response to pneumococcal capsular polysaccharides.

@article{Boudewijns2005BlockadeOC,
  title={Blockade of CTLA-4 (CD152) enhances the murine antibody response to pneumococcal capsular polysaccharides.},
  author={Micha{\"e}l Boudewijns and Axel Jeurissen and Margaretha Wuyts and Leen Moens and Louis Boon and Joost R J van Neerven and Ahmad Kasran and Lut Overbergh and Caroline Hilferink Lenaerts and Marc Waer and Chantal Mathieu and Jan L Ceuppens and Xavier Bossuyt},
  journal={Journal of leukocyte biology},
  year={2005},
  volume={78 5},
  pages={1060-9}
}
The capsular polysaccharides (caps-PS) of Streptococcus pneumoniae are classified as thymus-independent antigens. Nevertheless, T lymphocytes can modulate the antibody response to caps-PS. In this study, we show that anticytotoxic T lymphocyte-associated antigen 4 (CTLA-4) treatment, along with administration of caps-PS to BALB/c mice, resulted in a dose-dependent generation of a strong caps-PS-specific antibody response. Anti-CTLA-4 treatment had no effect on the immunoglobulin G (IgG… CONTINUE READING