Blockade of CD28/CTLA4-B7 pathway prevented autoantibody-related diseases but not lung disease in MRL/lpr mice.

Abstract

We studied the role of CD28/CTLA4 costimulatory T-cell activation pathway on the pathogenesis of MRL/lpr mice. Administration of CTLA4IgG from day 0 significantly inhibited autoantibody production such as anti-double-stranded DNA antibody and rheumatoid factor. In addition, end-organ diseases in kidney, salivary gland, and liver were significantly improved… (More)

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Cite this paper

@article{Takiguchi1999BlockadeOC, title={Blockade of CD28/CTLA4-B7 pathway prevented autoantibody-related diseases but not lung disease in MRL/lpr mice.}, author={Mitsuyoshi Takiguchi and M. Murakami and I. Nakagawa and Atsuo Yamada and Shunsuke Chikuma and Yosuke Kawaguchi and Ayumi Hashimoto and Toshimitsu Uede}, journal={Laboratory investigation; a journal of technical methods and pathology}, year={1999}, volume={79 3}, pages={317-26} }