Blockade of AMPA receptors reduces brain edema following opening of the blood-brain barrier.

@article{Westergren1993BlockadeOA,
  title={Blockade of AMPA receptors reduces brain edema following opening of the blood-brain barrier.},
  author={Irena Westergren and Barbro Birgitta Johansson},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1993},
  volume={13 4},
  pages={603-8}
}
The aim of our study was to evaluate whether blockade of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors could reduce brain edema in two experimental models of edema following opening of the blood-brain barrier (BBB). The brain specific gravity was determined 2 h after opening the BBB by a 30-s infusion of protamine sulfate (10 mg in 200 microliters 0.9% NaCl) or arabinose (1.5 or 1.8 mol/L, 0.06 ml.s-1) into the right internal carotid artery. Cisternal CSF was… CONTINUE READING