Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

@article{Wel2011BlockadeO5,
  title={Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment},
  author={Janelle H. P. van Wel and Kim P C Kuypers and Eef L Theunissen and Wendy M. Bosker and Katja Bakker and Johannes G. Ramaekers},
  journal={Neuropsychopharmacology},
  year={2011},
  volume={36},
  pages={1932-1939}
}
3,4-Methylenedioxymethamphetamine (MDMA) or ‘ecstasy’ has been associated with memory deficits during abstinence and intoxication. The human neuropharmacology of MDMA-induced memory impairment is unknown. This study investigated the role of 5-HT2A and 5-HT1A receptors in MDMA-induced memory impairment. Ketanserin is a 5-HT2A receptor blocker and pindolol a 5-HT1A receptor blocker. It was hypothesized that pretreatment with ketanserin and pindolol would protect against MDMA-induced memory… CONTINUE READING
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