Blockade of 5-HT-mediated enteric slow EPSPs by BRL 24924: gastrokinetic effects.

@article{Mawe1989BlockadeO5,
  title={Blockade of 5-HT-mediated enteric slow EPSPs by BRL 24924: gastrokinetic effects.},
  author={G M Mawe and Theresa A. Branchek and Michael David Gershon},
  journal={The American journal of physiology},
  year={1989},
  volume={257 3 Pt 1},
  pages={
          G386-96
        }
}
Two types of 5-hydroxytryptamine (5-HT) receptor, 5-HT1P and 5-HT3, have been identified physiologically on enteric neurons impaled by intracellular microelectrodes. Activation of 5-HT1P receptors evokes a long-lasting membrane depolarization associated with an increased input resistance, whereas stimulation of 5-HT3 receptors results in a brief depolarization during which the input resistance falls. Slow excitatory postsynaptic potentials (EPSPs) in myenteric type II-hyperpolarizing… CONTINUE READING

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