Blockade by psychotropic drugs of the muscarinic acetylcholine receptor in cultured nerve cells.

Abstract

The ability of antimuscarinics, tricyclic antidepressants, and antipsychotics to block the muscarinic acetylcholine receptor was determined using an assay for this receptor in cultured nerve cells. The technique involved the assay of receptor-mediated formation of guanosine 3',5'-cyclic phosphate (cyclic GMP) from radioactively labeled guanosine 5… (More)

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Cite this paper

@article{Richelson1977BlockadeBP, title={Blockade by psychotropic drugs of the muscarinic acetylcholine receptor in cultured nerve cells.}, author={Elliott Richelson and S Divinetz-Romero}, journal={Biological psychiatry}, year={1977}, volume={12 6}, pages={771-85} }