Blockade by narcotic drugs of naloxone-precipitated jumping in morphine-dependent mice.

Abstract

A dose regimen for administration of morphine, test drugs with potential to cause physical dependence and naloxone was determined to allow within one experimental day acquisition of morphine-dependent mice and evaluation of the narcotic drugs for their ability to prevent naloxone-precipitated jumping. This test procedure can be used to assess capacity of… (More)

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