Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by l-cis-diltiazem

@article{Haynes1992BlockOT,
  title={Block of the cyclic GMP-gated channel of vertebrate rod and cone photoreceptors by l-cis-diltiazem},
  author={Leroy W. Haynes},
  journal={The Journal of General Physiology},
  year={1992},
  volume={100},
  pages={783 - 801}
}
Inside-out patches were excised from catfish rod or cone outer segments. Single channel and macroscopic currents were recorded from GMP-gated channels activated by 1 mM cGMP in low divalent buffered saline. Currents were blocked by the application of micromolar concentrations of l-cis-diltiazem to the cytoplasmic side of the patch. The concentration dependence of block indicated that a single molecule was sufficient to block a channel and that all channels were susceptible to block. The… CONTINUE READING