Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine

@article{Kim2000BlockOS,
  title={Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine},
  author={Yon Sang Kim and Y. Shin and Chung-Soo Lee and Jin-Ho Song},
  journal={Brain Research},
  year={2000},
  volume={881},
  pages={190-198}
}
To elucidate the local anesthetic mechanism of diphenhydramine, its effects on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium currents in rat dorsal root ganglion (DRG) neurons were examined by the whole-cell voltage clamp method. Diphenhydramine blocked TTX-S and TTX-R sodium currents with K(d) values of 48 and 86 microM, respectively, at a holding potential of -80 mV. It shifted the conductance-voltage curve for TTX-S sodium currents in the depolarizing direction but… Expand
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