Block of potassium channels of the nodal membrane by 4-aminopyridine and its partial removal on depolarization

@article{Ulbricht1976BlockOP,
  title={Block of potassium channels of the nodal membrane by 4-aminopyridine and its partial removal on depolarization},
  author={Werner Ulbricht and Henry Wagner},
  journal={Pfl{\"u}gers Archiv},
  year={1976},
  volume={367},
  pages={77-87}
}
1. Voltage clamp experiments were done on single myelinated nerve fibres of the frog,Rana esculenta. 2. 53 μM 4-aminopyridine (4-AP) reducedI K to about one-fifth if tested with infrequent (1/min) and short (10 ms) depolarizing pulses; the onset time constant under these circumstances was ca. 160 s (14–15° C). After prolonged treatment the effect was virtually irreversible. 3. At equilibrium with 4-AP, increasing the frequency of short pulses removed part of the block, the block removal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 22 references

Voltage - dependent block of K channels by 4 - aminopyridine

  • A. M. Woodhull
  • 1976

: 4 - aminopyridine block of K channels and its partial relief on depolarization

  • H.-H. Wagner, W. Ulbricht
  • Abstr . 5 th Int . Biophys . Congr .
  • 1975

Effects of 4 - aminopyridine on the potassium currents in internally perfused giant axons of the squid

  • H. Meres, Y. Pichon
  • J . Physiol . ( Lond . )
  • 1975

Microwave spectra and structure of the amine group in 3 - aminopyridine and 4 - aminopyridine

  • B. Frankenhaeuser
  • J . chem . Soc . Faraday Trans . II
  • 1975

The actions of 4 - aminopyridine on the delayed potassium current in skeletal muscle fibres

  • B. Hille
  • J . Physiol . ( Lond . )
  • 1975

Action de la 4 - amino - pyridine sur la membrane de l ' axone isol 6 d ' Insecte

  • J. R. Schwarz, W. Vogel
  • C . R . Acad . Sci .
  • 1974

Selective inhibition of potassium current in the giant axon of the cockroach

  • M. Pelhate, B. Hue, Y. Pichon, J. Chanelet
  • J . Physiol . ( Lond . )
  • 1974

The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine

  • W. Ulbricht
  • J . gen . Physiol .
  • 1973

Similar Papers

Loading similar papers…