Block of induction and maintenance of calcium-induced LTP by inhibition of protein kinase C in postsynaptic neuron in hippocampal CA1 region.

Calcium-induced LTP (Ca-LTP) refers to the long-lasting potentiation of synaptic transmission in hippocampal synapses that can be induced by a transient (7-10 min) and small increase (from 2 mM to 4 mM) in extracellular calcium concentration. In this paper the effects of protein kinase C (PKC) inhibitors, polymyxin B (PMB) and PKC(19-31), given… (More)