Block of human heart hH1 sodium channels by amitriptyline.

  title={Block of human heart hH1 sodium channels by amitriptyline.},
  author={Carla Nau and Margaret R Seaver and S. Y. Wang and G. K. Wang},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={292 3},
Amitriptyline is a tricyclic antidepressant used to treat major depression and various neuropathic pain syndromes. This drug also causes cardiac toxicity in patients with overdose. We characterized the tonic and use-dependent amitriptyline block of human cardiac (hH1) Na(+) channels expressed in human embryonic kidney cells under voltage-clamp conditions. Our results show that, near the therapeutic plasma concentration of 1 microM, amitriptyline is an effective use-dependent blocker of hH1 Na… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 38 extracted citations


Publications referenced by this paper.
Showing 1-10 of 29 references

Similar Papers

Loading similar papers…