Block of human heart hH1 sodium channels by amitriptyline.

@article{Nau2000BlockOH,
  title={Block of human heart hH1 sodium channels by amitriptyline.},
  author={Carla Nau and Margaret R Seaver and S. Y. Wang and G. K. Wang},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={292 3},
  pages={1015-23}
}
Amitriptyline is a tricyclic antidepressant used to treat major depression and various neuropathic pain syndromes. This drug also causes cardiac toxicity in patients with overdose. We characterized the tonic and use-dependent amitriptyline block of human cardiac (hH1) Na(+) channels expressed in human embryonic kidney cells under voltage-clamp conditions. Our results show that, near the therapeutic plasma concentration of 1 microM, amitriptyline is an effective use-dependent blocker of hH1 Na… CONTINUE READING

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