Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore

@article{Winegar1991BlockOC,
  title={Block of current through single calcium channels by Fe, Co, and Ni. Location of the transition metal binding site in the pore},
  author={Bruce D. Winegar and Ronan Kelly and Jeffry B. Lansman},
  journal={The Journal of General Physiology},
  year={1991},
  volume={97},
  pages={351 - 367}
}
The blocking actions of Fe2+, Co2+, and Ni2+ on unitary currents carried by Ba2+ through single dihydropyridine-sensitive Ca2+ channels were recorded from cell-attached patches on myotubes from the mouse C2 cell line. Adding millimolar concentrations of blocker to patch electrodes containing 110 mM BaCl2 produced discrete excursions to the closed channel level. The kinetics of blocking and unblocking were well described with a simple model of open channel block. Hyperpolarization speeded the… CONTINUE READING
27 Citations
2 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

Kinetics and mechanism of reactions of main group metal ions with biological carriers

  • C. Edwards
  • Pure and Applied Chemistry
  • 1969

Similar Papers

Loading similar papers…