Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.

@article{Obata2000BlockOC,
  title={Block of cardiac ATP-sensitive K(+) channels reduces hydroxyl radicals in the rat myocardium.},
  author={Toshio Obata and Yasumitsu Yamanaka},
  journal={Archives of biochemistry and biophysics},
  year={2000},
  volume={378 2},
  pages={
          195-200
        }
}
The present study examined whether opening of an ATP-sensitive K(+) (K(ATP)) channel can induce hydroxyl free radical ((*)OH) generation in the rat myocardium. Sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused directly through a microdialysis probe to detect the generation of (*)OH as reflected by the nonenzymatic formation of 2,3-dihydroxybenzoic acid (DHBA). Induction of cromakalim (100 microM), a K(ATP) channel opener, through the microdialysis probe significantly… CONTINUE READING

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