Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs.

@article{Miyazaki1992BlockOC,
  title={Block of Ca2+ wave and Ca2+ oscillation by antibody to the inositol 1,4,5-trisphosphate receptor in fertilized hamster eggs.},
  author={Shunichi Miyazaki and Michisuke Yuzaki and Kazuto Nakada and Hideki Shirakawa and Shigetada Nakanishi and Shinji Nakade and Katsuhiko Mikoshiba},
  journal={Science},
  year={1992},
  volume={257 5067},
  pages={251-5}
}
The concentration of cytoplasmic free calcium (Ca2+) increases in various stimulated cells in a wave (Ca2+ wave) and in periodic transients (Ca2+ oscillations). These phenomena are explained by inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release (IICR) and Ca(2+)-induced Ca2+ release (CICR) from separate intracellular stores, but decisive evidence is lacking. A monoclonal antibody to the IP3 receptor inhibited both IICR and CICR upon injection of IP3 and Ca2+ into hamster eggs, respectively… CONTINUE READING
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