Corpus ID: 21887489

Block effects of IHC-72 on calcium current in single guinea pig cardiac myocytes.

@article{Ji1994BlockEO,
  title={Block effects of IHC-72 on calcium current in single guinea pig cardiac myocytes.},
  author={G. Ji and J. Zhang},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1994},
  volume={16 2},
  pages={
          85-9
        }
}
  • G. Ji, J. Zhang
  • Published 1994
  • Chemistry, Medicine
  • Methods and findings in experimental and clinical pharmacology
Block of the calcium current by IHC-72 in single ventricular myocytes isolated from guinea pig was studied by using the whole-cell patch clamp technique. IHC-72 in micromolar concentrations depressed the calcium current in a concentration-dependent manner, with an IC50 of 0.06 +/- 0.02 mcmol/l. After application of IHC-72 the peak calcium current began to decrease within 1 min and reached a steady state within 10 min. The current-voltage relationship for the calcium current peak was not changed… Expand
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