Blinded and unblinded internal pilot study designs for clinical trials with count data.

@article{Schneider2013BlindedAU,
  title={Blinded and unblinded internal pilot study designs for clinical trials with count data.},
  author={S. Schneider and H. Schmidli and T. Friede},
  journal={Biometrical journal. Biometrische Zeitschrift},
  year={2013},
  volume={55 4},
  pages={
          617-33
        }
}
  • S. Schneider, H. Schmidli, T. Friede
  • Published 2013
  • Computer Science, Medicine
  • Biometrical journal. Biometrische Zeitschrift
  • Internal pilot studies are a popular design feature to address uncertainties in the sample size calculations caused by vague information on nuisance parameters. Despite their popularity, only very recently blinded sample size reestimation procedures for trials with count data were proposed and their properties systematically investigated. Although blinded procedures are favored by regulatory authorities, practical application is somewhat limited by fears that blinded procedures are prone to… CONTINUE READING
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