Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump.

@article{Aebischer1988BlindendedSG,
  title={Blind-ended semipermeable guidance channels support peripheral nerve regeneration in the absence of a distal nerve stump.},
  author={P. Aebischer and V. Gu{\'e}nard and Shelley R. Winn and Robert F. Valentini and Pierre M. Galletti},
  journal={Brain research},
  year={1988},
  volume={454 1-2},
  pages={179-87}
}
The presence of a distal nerve segment is considered to be essential for peripheral nerve regeneration through impermeable synthetic guidance channels. The use of a perm-selective material may provide a more appropriate regenerating environment by allowing solute exchange across the wall of the channel. We compared perm-selective acrylic copolymer (AC) channels with impermeable silicone elastomer (SE) channels in terms of regeneration in the absence of a distal nerve stump. Cohorts of 6 animals… CONTINUE READING
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