Blind Color Decomposition of Histological Images

  title={Blind Color Decomposition of Histological Images},
  author={Milan Gavrilovic and Jimmy C. Azar and Joakim Lindblad and Carolina W{\"a}hlby and Ewert Bengtsson and Christer Busch and Ingrid Carlbom},
  journal={IEEE Transactions on Medical Imaging},
Cancer diagnosis is based on visual examination under a microscope of tissue sections from biopsies. But whereas pathologists rely on tissue stains to identify morphological features, automated tissue recognition using color is fraught with problems that stem from image intensity variations due to variations in tissue preparation, variations in spectral signatures of the stained tissue, spectral overlap and spatial aliasing in acquisition, and noise at image acquisition. We present a blind… CONTINUE READING