Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.

@article{Brzezinski2010Blimp1CP,
  title={Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.},
  author={Joseph A Brzezinski and Deepak Ashok Lamba and Thomas A. Reh},
  journal={Development},
  year={2010},
  volume={137 4},
  pages={619-29}
}
Photoreceptors, rods and cones are the most abundant cell type in the mammalian retina. However, the molecules that control their development are not fully understood. In studies of photoreceptor fate determination, we found that Blimp1 (Prdm1) is expressed transiently in developing photoreceptors. We analyzed the function of Blimp1 in the mouse retina using a conditional deletion approach. Developmental analysis of mutants showed that Otx2(+) photoreceptor precursors ectopically express the… CONTINUE READING

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