Blimp1 Expression Predicts Embryonic Stem Cell Development In Vitro

@article{Chu2011Blimp1EP,
  title={Blimp1 Expression Predicts Embryonic Stem Cell Development In Vitro},
  author={Li-Fang Chu and M. Azim Surani and Rudolf Jaenisch and Thomas P. Zwaka},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={1759-1765}
}
Despite recent critical insights into the pluripotent state of embryonic stem cells (ESCs), there is little agreement over the inaugural and subsequent steps leading to its generation [1-4]. Here we show that inner cell mass (ICM)-generated cells expressing Blimp1, a key transcriptional repressor of the somatic program during germ cell specification [5, 6], emerge on day 2 of blastocyst culture. Single-cell gene expression profiling indicated that many of these Blimp1-positive cells coexpress… CONTINUE READING

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