Blimp-1 overexpression is associated with low HIV-1 reservoir and transcription levels in central memory CD4+ T cells from elite controllers.

@article{Masson2014Blimp1OI,
  title={Blimp-1 overexpression is associated with low HIV-1 reservoir and transcription levels in central memory CD4+ T cells from elite controllers.},
  author={Adele de Masson and Amos Kirilovsky and Rima Zoorob and V{\'e}ronique Avettand-Fenoel and V{\'e}ronique Morin and Anne Oudin and Benjamin Descours and Christine Rouzioux and Brigitte Autran},
  journal={AIDS},
  year={2014},
  volume={28 11},
  pages={1567-77}
}
OBJECTIVES The aim of the study was to determine the molecular mechanisms underlying the quasi-equilibrium between HIV and its host in the model of functional cure represented by elite controllers who spontaneously maintain exceptionally low levels of HIV reservoirs. DESIGN Whole-genome transcriptional study and quantification of the cell-associated HIV DNA and HIV RNA levels of the four major resting CD4 T-cell subsets in HIV-1-infected elite controllers, viremic long-term nonprogressors… CONTINUE READING