Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology

  title={Blimp-1-Dependent IL-10 Production by Tr1 Cells Regulates TNF-Mediated Tissue Pathology},
  author={Marcela Montes de Oca and Rajiv Kumar and Fabian de Labastida Rivera and Fiona H Amante and Meru Sheel and Rebecca J. Faleiro and Patrick T. Bunn and Shannon E. Best and Lynette Beattie and Susanna S Ng and Chelsea L. Edwards and Werner Muller and Erika Cretney and Stephen L Nutt and Mark J Smyth and Ashraful Haque and Geoffrey R Hill and Shyam Sundar and Axel Kallies and Christian R Engwerda and Phillip Scott},
  booktitle={PLoS pathogens},
Tumor necrosis factor (TNF) is critical for controlling many intracellular infections, but can also contribute to inflammation. It can promote the destruction of important cell populations and trigger dramatic tissue remodeling following establishment of chronic disease. Therefore, a better understanding of TNF regulation is needed to allow pathogen control without causing or exacerbating disease. IL-10 is an important regulatory cytokine with broad activities, including the suppression of… CONTINUE READING
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